Role of tumor necrosis factor alpha in development of immunity against Cryptosporidium parvum infection |
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| Authors: | Lean I-Sarah Lacroix-Lamandé Sonia Laurent Fabrice McDonald Vincent |
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| Affiliation: | Barts and the London School of Medicine, Institute of Cell and Molecular Science, Centre for Gastroenterology, Turner Street, London E1 2AD, United Kingdom. |
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| Abstract: | Tumor necrosis factor (TNF-alpha) significantly reduced Cryptosporidium parvum development in a murine enterocyte cell line, and a key mechanism of action appeared to be inhibition of parasite invasion. However, TNF-alpha-deficient mice controlled infection as effectively as wild-type mice. This suggests that TNF-alpha might have only a redundant role for establishing immunity against C. parvum. |
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