| 参芪养心颗粒对冠脉结扎致犬急性心肌缺血影响的实验研究 |
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| 引用本文： | 韩晓江,杜锦辉,关敬之,毕连宝,刘雁飞,呼格吉乐.参芪养心颗粒对冠脉结扎致犬急性心肌缺血影响的实验研究[J].天津中医药,2019,36(9):916-920. |
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| 作者姓名： | 韩晓江 杜锦辉 关敬之 毕连宝 刘雁飞 呼格吉乐 |
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| 作者单位： | 内蒙古医科大学附属医院中医科;内蒙古国际蒙医医院内蒙古医科大学附属蒙医医院药学部;内蒙古医科大学附属医院影像科;内蒙古医科大学附属医院检验科 |
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| 基金项目： | 2017年度内蒙古自治区卫生计生科研项目（201702014）。 |
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| 摘 要： | 目的]研究参芪养心颗粒对冠脉结扎致犬急性心肌缺血的影响。方法]冠脉结扎致犬急性心肌缺血,观察参芪养心颗粒对犬心肌缺血区心外膜电图(N-ST)、冠脉血管阻力(CVR)、心肌血流量(MBF)、心肌耗氧量(MOC)、左心室心肌细胞苏木精-伊红(HE)染色病理变化以及心肌梗死区质量的影响。结果]与模型对照组比较参芪养心颗粒中剂量组(5.46 g生药/kg)和参芪养心颗粒高剂量组(10.92 g生药/kg)可显著降低犬心肌缺血区N-ST。与模型对照组比较参芪养心颗粒中剂量组(5.46 g生药/kg)和参芪养心颗粒高剂量组(10.92 g生药/kg)可显著降低冠脉血管阻力。与模型对照组比较参芪养心颗粒中剂量组(5.46 g生药/kg)和参芪养心颗粒高剂量组(10.92 g生药/kg)可显著增加犬急性心肌缺血模型的心肌血流量。与模型对照组比较参芪养心颗粒高剂量组(10.92 g生药/kg)可显著降低心肌耗氧量。与模型对照组比较参芪养心颗粒中剂量组(5.46g生药/kg)和参芪养心颗粒高剂量组(10.92 g生药/kg)可显著降低心肌梗死区质量。结论]参芪养心颗粒对冠脉结扎致犬急性心肌缺血模型具有保护作用。
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| 关 键 词： | 参芪养心颗粒 急性心肌缺血 Beagle犬 |
| 收稿时间： | 2019/5/15 0:00:00 |
Experimental study on effect of Shenqi Yangxin Granule on dogs with acute myocardial ischemia caused by coronary ligation |
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| HAN Xiaojiang,DU Jinhui,GUAN Jingzhi,BI Lianbao,LIU Yanfei and Hugejile.Experimental study on effect of Shenqi Yangxin Granule on dogs with acute myocardial ischemia caused by coronary ligation[J].Tianjin Journal of Traditional Chin Medicine,2019,36(9):916-920. |
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| Authors: | HAN Xiaojiang DU Jinhui GUAN Jingzhi BI Lianbao LIU Yanfei and Hugejile |
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| Institution: | Department of Traditional Chinese Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, China,Department of Traditional Chinese Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, China,Department of Pharmacy, Inner Mongolia International Mongolian Hospital, Hohhot 010065, China,Department of Traditional Chinese Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, China,Department of Imaging, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, China and Department of Clinical Laboratory, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, China |
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| Abstract: | Objective] To study the effects of Shenqi Yangxin Granule on acute myocardial ischemia in dogs induced by coronary artery ligation.Methods] Acute myocardial ischemia was induced by coronary artery ligation. The effects of Shenqi Yangxin Granule on N-ST,coronary vascular resistance,myocardial blood flow,myocardial oxygen consumption and myocardial infarct size were observed.Results] Compared with the model control group,the Shenqi Yangxin granules in the middle dose group (5.46 g crude drug/kg) and the Shenqi Yangxin Granule high dose group (10.92 g crude drug/kg) significantly reduced the N-ST in the canine myocardial ischemic area. Compared with the model control group,the Shenqi Yangxin Granules middle dose group (5.46 g crude drug/kg) and Shenqi Yangxin Granule high dose group (10.92 g crude drug/kg) can significantly reduce coronary vascular resistance. Compared with the model control group,the Shenqi Yangxin Granule middle dose group (5.46 g crude drug/kg) and the Shenqi Yangxin Granule high dose group (10.92 g crude drug/kg) significantly increased myocardial blood flow in the canine acute myocardial ischemia model. Compared with the model control group,the high dose group of Shenqi Yangxin Granule (10.92 g crude drug/kg) can significantly reduce myocardial oxygen consumption. Compared with the model control group,the Shenqi Yangxin Granule middle dose group (5.46 g crude drug/kg) and the Shenqi Yangxin Granule high dose group (10.92 g crude drug/kg) can significantly reduce the area of myocardial infarction.Conclusion] Shenqi Yangxin Granule has protective effect on acute myocardial ischemia induced by coronary artery ligation. |
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| Keywords: | Shenqi Yangxin Granule acute myocardial ischemia Beagle dog |
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