| 软坚散结法治疗非小细胞肺癌的疗效及安全性的Meta分析 |
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| 引用本文： | 张立双,杨丰文,李雪梅,张俊华,金鑫瑶,张明妍,冯睿,赵宏杰,季昭臣.软坚散结法治疗非小细胞肺癌的疗效及安全性的Meta分析[J].天津中医药,2019,36(1):40-45. |
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| 作者姓名： | 张立双 杨丰文 李雪梅 张俊华 金鑫瑶 张明妍 冯睿 赵宏杰 季昭臣 |
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| 作者单位： | 天津中医药大学循证医学中心;天津中医药大学附属保康医院 |
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| 基金项目： | 国家自然科学基金项目（81102733）；天津市青年拔尖人才计划项目（201504）。 |
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| 摘 要： | 目的]系统评价软坚散结方药治疗非小细胞肺癌(NSCLC)的有效性和安全性。方法]计算机检索中文全文期刊数据库、万方数据库、中国生物医学文献数据库及PubMed、Embase、The Cochrane Library数据库,搜集软坚散结方药治疗非小细胞肺癌的临床随机对照试验(RCT),检索时限均为建库至2017年10月16日。由2位评价员独立筛选文献、提取资料并评价纳入文献的方法学质量,采用Stata 12.0软件进行统计分析。结果]共纳入40个RCT共计3 201例NSCLC患者,涉及汤剂、丸剂、胶囊、合剂、注射剂5种剂型,34种干预措施。Meta分析结果显示,与单纯化疗药相比,软坚散结方药联合化疗药可提高NSCLC患者的临床疗效,改善患者的生活质量,延长NSCLC患者无进展生存期,降低化疗药物不良反应。结论]软坚散结方联合化疗药的临床疗效、生存质量及降低不良反应方面优于单纯的化疗组。由于纳入研究质量较低,该结论仍需开展高质量研究进行验证。
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| 关 键 词： | 软坚散结法 非小细胞肺癌 Meta分析 系统评价 临床随机对照试验 |
| 收稿时间： | 2018/8/30 0:00:00 |
Efficacy and safety of resolving hard lump for non-small cell lung cancer: A Meta-analysis |
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| ZHANG Lishuang,YANG Fengwen,LI Xuemei,ZHANG Junhu,JIN Xinyao,ZHANG Mingyan,FENG Rui,ZHAO Hongjie and JI Zhaochen.Efficacy and safety of resolving hard lump for non-small cell lung cancer: A Meta-analysis[J].Tianjin Journal of Traditional Chin Medicine,2019,36(1):40-45. |
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| Authors: | ZHANG Lishuang YANG Fengwen LI Xuemei ZHANG Junhu JIN Xinyao ZHANG Mingyan FENG Rui ZHAO Hongjie and JI Zhaochen |
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| Institution: | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,Baokang Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China and Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract: | |
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| Keywords: | resolving hard lump non-small cell lung cancer Meta-analysis rystematic review randomized controlled trial |
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