Correlation between active E-rosettes and antigens defined on peripheral lymphocytes by OKT 4 and OKT 8 monoclonal antibodies |
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Authors: | J Chassagne P Chollet J P Ferriere C Touzet F Rusé-Riol R Plagne |
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Affiliation: | Centre Jean Perrin and I.N.S.E.R.M. U71, BP 392, 63011 Clermont-Ferrand Cedex, France |
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Abstract: | A relationship has been sought between the classical marker, active E-rosette and the surface antigens of T-lymphocytes, defined by OKT 4 and 8 monoclonal antigens, in the peripheral blood of normal human people. It was found that no significant correlation existed in the case of OKT 4 antigen; conversely the OKT 8-positive cells were significantly enriched after E-rosette-forming cell isolation (about 2.5 times in comparison with the negatively selected cells). In this latter case, some partial correlation could exist between SRBC-high affinity of T-lymphocytes and the subsets defined by OKT 8 antigen. |
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Keywords: | T-subpopulations active E-rosettes monoclonal antibodies OKT 4 and 8 normal human subjects |
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