Effects of several antifungal drug combinations against clinical and environmental isolates of Cryptococcus neoformans from China |
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Authors: | Zhu Li-Ping Gil-Lamaignere Cristina Müller Frank-Michael C |
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Affiliation: | Department of Pediatrics, University of Würzburg, Würzburg, Germany. |
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Abstract: | The in vitro interactions of caspofungin (CSP) with terbinafine (TRB) and ravuconazole (RVC) with 5-fluorocytosine (5-FC) were tested against 82 clinical and environmental isolates of Cryptococcus neoformans from China. The interaction of CSP with TRB proved synergistic against those isolates with a CSP MIC < or =2 microg ml-1 (5% of the isolates), additive against 42% of the isolates and indifferent against 53%. The effects of RVC with 5-FC were synergistic, additive or indifferent against 8%, 26% and 67% of the isolates, respectively. No antagonistic effects were found among any of the drugs. The combinations of CSP with TRB and RVC with 5-FC may display beneficial effects in a strain-dependent manner, while in no case showed antagonistic effects. These data might be of use to design safer and more efficient treatments for patients with cryptococcosis and warrant further evaluation. |
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Keywords: | Cryptococcus neoformans antifungal agents combinations susceptibility |
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