急性心肌梗死不同梗死部位和病变血管与肌钙蛋白Ⅰ和NT-proBNP的变化

目的探讨急性ST段抬高型广泛前壁和下壁心肌梗死，不同梗死部位和相应病变血管血浆心肌肌钙蛋白I和N氨基酸末端脑钠肽前体的变化。方法69例急性心肌梗死患者根据心电图、心肌坏死标记物及冠脉造影分为急性sT段抬高广泛前壁心肌梗死组37例和急性下壁心肌梗死组32例。于发病24h内抽取静脉血，行血浆cTnI、NT-proBNP检测。结果急性ST段抬高广泛前壁和下壁心肌梗死血浆cTnI、NT-proBNP均高于正常，且广泛前壁心肌梗死组的cTnI、NT-proBNP高于下壁心肌梗死组，两者比较，NT-proBNP差异有统计学意义（P〈0．05），而cTnI差异无统计学意义（P〉0．05）。结论crrnI、NT-proBNP增高可反映急性心肌梗死心肌损害的程度及预后。

Clinical observation to different locations of AM][ cTnI and BNP in plasma

Objective To explore the relationship between the different locations of acute myocardial infarction with elevated ST segment （STEMI） as well as coronary narrowing and the levels of cardiac troponin I（eTnI） and N - terminal pro - B - typenatriuretic pep- tide（ NT - proBNP） in plasma. Methods Sixty - nine patients of STMI were divided into group - 1 （ n = 37, the infarction was located in the wide anterior wall） and group -2 （n = 32, the infarction was located in the inferior wall） by ECG and coronary angiogram. The cTnI and NT - proBNP in plasma were tested for all of the patients with venous blood samples taken within 24 hours of the AMI. Results The cTnI and NT - proBNP were elevated over the normal level significantly in both of the two groups. That was higher in group - 1 than that of group - 2. The NT - proBNP is significant difference between the two groups （ P 〈 0.05 ） but the eTnI without significant difference （ P 〉 0. 05 ）. Conclusion Both of cTnI and NT - proBNP are risk factors of AMI and may reflect the extent and prognosis of the myocar- dial injury.