降钙素原与乳酸水平对脓毒症风险分层及预后判断临床价值探讨

目的：探讨血降钙素原（PCT）与乳酸2种生物标记物对脓毒症患者风险分层及预后判断的临床价值。方法：57例脓毒症患者按病情严重程度分为早期脓毒症组、严重脓毒症组和脓毒症休克组;回顾性研究将所有患者根据预后分为生存组及死亡组。分别比较组间PCT、乳酸水平和APACHEⅡ评分,观察标记物对风险分层及预后评估的临床价值。结果：不同严重程度的三组患者中,2种标记物水平组间比较差异均有统计学意义（P〈0.05）,脓毒性休克组与其他组APACHEⅡ评分比较差异有统计学意义（P〈0.05）。生存组与死亡组PCT、乳酸水平与APACHEⅡ评分比较差异均有统计学意义（P〈0.05）。结论：血降钙素原与乳酸水平对脓毒症风险分层与预后判断有较好的预测意义,联合检测可提高预测的敏感性。

The Value of Serum Procalcitonin and Two Biomarkers of Lactate on Risk Stratification and Prognosis Judgement of Patients with Sepsis

Objective：To explore the prognostic significance of serum procalcitonin （PCT） and lactate in patients with the sepsis.Methods：A total of 57 patients with sepsis were divided into 3 groups according to clinical severity：early sepsis group,sever sepsis group and sepsis shock group.In retrospective studies,all the patients were divided into survival group and non-survival group according to mortality.To study the difference of serum PCT,lactate and APACHEⅡ scores in all groups and explore the prognostic significance of the biological markers.Results：The concentration of PCT and lactate varied significantly in different clinical severity groups.Meanwhile,the significant difference of the concentration of PCT,lactate and APACHEⅡ scores was observed in survival group and non-survival group.Conclusion：Serum PCT and lactate are biomarkers in predicating the sepsis prognosis and can reveal the risk stratification.