2型糖尿病与脂代谢异常的相关性研究

目的探讨新诊断2型糖尿病（diabetes mellitus，DM）患者体重指数（body mass index，BMI）与胰岛素抵抗（insulin resistance，IR）及血脂的关系。方法128名新诊断2型DM（T2DM）根据体重指数分为三组（肥胖组、超重组、体重正常组、），测定三组受试者血糖、胰岛素及血脂水平，用HOMA模型公式计算胰岛素抵抗指数（HOMA—IR）。结果肥胖组HOMA—IR明显高于超重组及体重正常组（P〈0．001），而超重组HOMA—IR亦高于体重正常的DM组（P〈0．01）；甘油三酯（TG）水平在肥胖组明显高于其他两组，高密度脂蛋白（HDL）则低于其他两组；随着BMI升高，血压有增高趋势。结论初诊肥胖及超重2型DM患者与胰岛素抵抗、血脂异常、高血压相关。

THE RELATIONSHIP BETWEEN TYPE 2 DIABETES MELLITUS AMD DYSLIPIDEMIA

Objective To explore the relationship between body mass index(BMI) and insulin resistance(IR) and the level of blood lipids in newly diagnosed type 2 diabetes mellitus(T2DM).Methods 128 cases of newly diagnosed diabetic patients were divided into three groups by BMI,The level of serum lipids,blood glucose,glucosylated hemoglobin(HbAlc) and fasting insulin(FINS) were tested.Blood pressure(BP)was measured.HOMA-IR and HOMA-IA were calculated with Homeostasis model assessment(HOMA).Results HOMA-IR was higher in obese group than in the other two groups.The higher level of serum triglyceride(TG)was observed in obese newly diagnosed DM patients.Blood pressure of obesity was higher than others.Conclusion Among newly diagnosed T2DM BMI was related with insulin resistance,dyslipidemia and hypertension.