| 银耳制剂对受照射荷瘤小鼠免疫功能保护作用的研究 |
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| 引用本文： | 郑仕中,张铭.银耳制剂对受照射荷瘤小鼠免疫功能保护作用的研究[J].中国肿瘤临床,1993,20(6):451-454. |
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| 作者姓名： | 郑仕中 张铭 |
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| 作者单位： | 中国医学科学院放射医学研究所，中国医学科学院放射医学研究所，白求恩医科大学预防医学院放射生物室，中国医学科学院放射医学研究所，中国医学科学院放射医学研究所 (天津市300192)，(天津市300192)，(天津市300192) |
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| 摘 要： | 荷S_(180)肉瘤小鼠ip银耳制剂(TFB)200mg/kg·d×7d。在第3、5和7天注药后40分钟分别荷瘤局部照射X射线5Gy。停药后早期,TFB能明显增加受照射荷瘤鼠的脾重、脾有核细胞数和胸腺细胞~3H—TdR自发掺入率;显著提高NK细胞和ADCC活性及增强脾细胞产生IL-2的能力,但不影响胸腺重量和胸腺细胞数。
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| 关 键 词： | 银耳 肉瘤 免疫功能 小鼠 |
Study of Protective Effect of Tremella Fuciformis Berk Preperation(TFB)on Immunity of Irradiated Tumor-bearing Mice |
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| Zheng Shi-Zhong Institute of Radiation Medicine,Chinese Academy of Medical Sciences,Tianjin.Study of Protective Effect of Tremella Fuciformis Berk Preperation(TFB)on Immunity of Irradiated Tumor-bearing Mice[J].Chinese Journal of Clinical Oncology,1993,20(6):451-454. |
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| Authors: | Zheng Shi-Zhong Institute of Radiation Medicine Chinese Academy of Medical Sciences Tianjin |
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| Abstract: | Sarcoma 180 tumor cells were transplanted subcutaneously into the right hind leg of C_(57)BL/6 mice. One day after transplantation,TFB was injected intraperitoneally at a dosage of 200mg/kg daily for 7 days. In the group treated in combination with TFB and local irradiation which was given on the 3rd, 5th and 7th day at a dosage of 5Gy of X-ray for 40 minutes after administration of TFB. The results showed that a remarkable increase of spleen weight,num- ber of splenocytes,and the ~3H-TdR spontaneous incorporation rate of thymocytes were found soon after TFB being ad- ministered. However,there were no significant changes in thymus weight nor number of thymocytes. Moreover,TFB was capable in augmenting the activity of both the natural killer cell and antibody-dependent cell-mediated cytotoxicity in ad- dition in improving the ability of solenocytes to produce IL-2 under induction of ConA. |
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| Keywords: | Tremella fuciformis berk(TFB) Sarcoma 180 Immunity Mice |
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