肝动脉门静脉栓塞治疗肝癌

本文首次报告碘化油加抗癌药经肝动脉门静脉栓塞治疗不能手术切除的晚期肝癌9例,计肝细胞癌7例,胆管细胞癌1例,结肠癌术后肝转移1例。5例为巨块型肝细胞癌(直径为7～16cm),4例为多发结节型。X线证实有4/7的肝细胞癌侵犯了肝内门静脉,提示门静脉内用药的必要性。治疗后,5例巨块型病灶明显缩小,AFP增高者术后均有不同程度下降。生存 15、12、9、8和 6个月者各为1,2,1,2和2例,1例失访。

Hepatic Arterial end Portal Venous Embolization in the Treatment of Liver Cancer

Embolization of both hepatic artery and portal vein was performed in 9 patients with advanced liver cancer.Histologic types consisted of 7 hepatocellular carcinomas, one cholangiocarcinoma and one metastasis from colon carcinoma.Operation was done by injecting cytotoxic drugs and iodized oil mixed with 5-Fu through two catheters into the gastroepiploic artery and gastroepiploic vein respectively. Five patients soffered from huge nodular hepatoma,the size ranged from 7 to 16cm across. Four cases were of the multiple nodular type. After embolization the 5 huge nodular hepetomas were all significantly reduced in size and all demonstrated AFP de- cline. In this series one patient survived for 15 months, 2 cases 12 months, 2 eight months, 1 nine months, 2 six months and 1 lost to follow-up. X-ray examination demonstrated that 4/7 hepatic carcinomas had involved intrahepatic portal vein,suggesting the necessity of administering anticancer drugs through the portal vein.