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| 药物从多孔骨架聚合物系统中恒速释放的机理 | |
| 引用本文： | 李艳丽,程国利,李凌冰. 药物从多孔骨架聚合物系统中恒速释放的机理[J]. 生物医学工程研究, 2002, 21(1): 1-4 |
| 作者姓名： | 李艳丽 程国利 李凌冰 |
| 作者单位： | 1. 济南市第四人民医院,济南,250031 2. 山东大学校医院内科,济南,250100 3. 山东大学西区药学院药剂教研室,济南,250012 |
| 摘 要： | 以组分的连续性方程为基础 ,建立了药物从多孔骨架聚合物系统中释放的数学模型。在模型中引入相对渗透速度来刻画药物释放过程中不同机理的影响。对药物从多孔骨架聚合物系统中non -Fickian扩散现象进行了研究 ,特别对药物溶出机制控制的恒速释药现象进行了解释。 |
| 关 键 词： | 连续性方程 多孔骨架聚合物 数学模型 摄动方法 |
Mathematical Model of Drug Release From Porous Polymer |
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| Li Yanli Cheng Guoli Li Lingbing. Mathematical Model of Drug Release From Porous Polymer[J]. Journal Of Blomedical Englneerlng Research, 2002, 21(1): 1-4 | |
| Authors: | Li Yanli Cheng Guoli Li Lingbing |
| Affiliation: | Li Yanli 1 Cheng Guoli 2 Li Lingbing 3 1 |
| Abstract: | A mathematical model describing the drug release from porous polymer was established by using the species continuity equation.The relative permeating rate was introduced to describe the effects of the different physical processes. An asymptotic solution has been obtained by using the perturbation theory.The whole process of the drug release from porous polymer was analysized,especially the process controlled by drug dissolution. |
| Keywords: | Continuity equation Porous polymer Mathematical model Perturbation theory |
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