| 环氧化酶-2和血管内皮生长因子在喉癌中的表达及临床意义 |
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| 引用本文： | 陈祖尧,余玲,粱灼萍,刘文军,黎万荣,覃纲.环氧化酶-2和血管内皮生长因子在喉癌中的表达及临床意义[J].中国耳鼻咽喉头颈外科,2009(3). |
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| 作者姓名： | 陈祖尧 余玲 粱灼萍 刘文军 黎万荣 覃纲 |
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| 作者单位： | 泸州医学院附属医院耳鼻咽喉头颈外科;泸州医学院附属医院眼科; |
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| 基金项目： | 四川省应用基础研究项目(05JY029-104)资助 |
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| 摘 要： | 目的研究环氧化酶-2(Cyclooxygenase-2,COX-2)和血管内皮生长因子(vascular endothelial growth factor,VEGF)在喉癌中的表达及临床意义。方法采用免疫组化SP法检测65例喉癌组织及34例癌旁组织中COX-2和VEGF表达,并结合相关临床病理参数进行分析。结果COX-2和VEGF在喉癌中阳性表达率分别为63.08%和70.77%,均高于癌旁组织中的表达(P<0.05),且两者表达呈显著相关性(P<0.05)。COX-2表达与T分期和临床分期相关,VEGF表达则与临床分期和淋巴结转移相关(P<0.05)。生存分析显示COX-2和VEGF阳性表达和阴性表达患者无瘤生存率和总生存率差异均有统计学意义(P<0.05)。结论COX-2和VEGF在喉癌组织表达异常增高,其在喉癌发生发展中可能发挥重要作用,且两指标的表达与喉癌不良预后有关。
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| 关 键 词： | 环氧化酶2 血管内皮生长因子类 喉肿瘤 癌 鳞状细胞 血管生成 生理性 |
The expression of COX-2 and VEGF in laryngeal carcinoma tissue and its clinical significance |
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| CHEN Zuyao,YU Ling,LIANG Zhuoping,LIU Wenjun,LI Wanrong,QIN Gang.The expression of COX-2 and VEGF in laryngeal carcinoma tissue and its clinical significance[J].Chinese Archives of Otolaryngology-Head and Neck Surgery,2009(3). |
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| Authors: | CHEN Zuyao YU Ling LIANG Zhuoping LIU Wenjun LI Wanrong QIN Gang |
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| Institution: | 1 Department of Otolaryngology Head and Neck Surgery;2 Department of Ophthalmology;Affiliated Hospital of Luzhou Medical College;Luzhou;Sichuan;646000;China |
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| Abstract: | OBJECTIVE To investigate the expression of Cyclooxygenase-2(COX-2)andVascular endothelial growth factor(VEGF)in laryngeal carcinoma tissue and its clinical significance. METHODS Sixty-five samples of laryngeal carcinoma and thirty-four biopsies of adjacent noncancerous tissue were immunohistochemically examined for expression of COX-2 and VEGF, whose relationship with clinicopathological parameters was also analysied. RESULTS Percentages of COX-2 and VEGF expression in laryngeal carcinoma tissue were 63.08%... |
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| Keywords: | Cyclooxygenase2 Vascular Endothelial Growth Factors Laryngeal Neoplasms Carcinoma Squamous cell Neovascularization Physiologic |
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