Suppressive effect of anti-rheumatic drugs on interleukin-1 beta release from human peripheral blood monocytes |
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| Authors: | M Okamoto M Sasano M Goto K Nishioka S Aotsuka K Nakamura R Yokohari |
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| Affiliation: | Institute of Rheumatology, Tokyo Women's Medical College, Japan. |
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| Abstract: | We developed an ELISA system for human IL-1 alpha and -beta release from silica-stimulated monocytes from healthy volunteers and tested the effect of several anti-rheumatic drugs including nonsteroidal anti-inflammatory drug (Ibuprofen). Anti-rheumatic drugs including Auranofin and Sulphasalazine suppressed IL-1 beta release significantly at therapeutic concentrations, whereas Bucillamine, Lobenzarit, D-Penicillamine and Ibuprofen did not. These results suggest a possible immunotherapeutic effectiveness of some anti-rheumatic drugs on rheumatoid arthritis through their inhibition of IL-1 beta release. |
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