1996—2006年南京地区结核病耐药状况分析

目的　了解南京地区近年来结核病耐药的发展趋势。方法 对1996—2006年南京市胸科医院肺结核病例采用绝对浓度间接法进行了10种常用抗结核药物的敏感试验并对结果进行分析。结果 各年每种抗结核药物的耐药率在一定范围内上下波动,但是耐多药率却是呈现逐步上升趋势,一线抗结核药物的耐药率明显高于二线抗结核药物的耐药率。结论 耐多药的发展趋势对目前以INH和RFP为主要抗结核药物的治疗方案构成了巨大的威胁,尽快开发新的低毒高效的抗结核药物是解决目前抗结核治疗困境的当务之急。

Analysis of drug resistance trend of Mycobacterium tuberculosisin in Nanjing region

Objective To analyze the drug resistance trend of Mycobacterium tuberculosis in Nanjing region. Method Absolute concentration method was used to detect the sensitivity of the 10 most used mycobacterium drugs. Results Resistance rate of each anti-tuberculosis drug fluctuated in some range, while resistance rate to multi-drug increased year by year. The resistant rate to first-line anti-tuberculosis drugs was fairly higher than to second-line anti-tuberculosis drugs. Conclusion The trend of resistance rate has been a serious threat to current therapy protocol of tuberculosis. It was imperative that new generation anti-tuberculosis drugs, with little adverse effect, should be developed to solve current dilemma of tuberculosis therapy.