硫酸钙骨水泥修复骨质疏松兔胫骨平台骨折的研究

目的探讨硫酸钙对骨折修复活动的影响。方法建立兔骨质疏松胫骨平台塌陷骨折模型，用硫酸钙填充植骨，进行一般观察、大体X线及骨密度fBMD）分析。结果普通X线观察提示骨折区填充的硫酸钙逐渐降解吸收，被新生的骨组织替代。骨水泥治疗组兔硫酸钙骨水泥填充后1、2、3、4、6、8、12周骨折处样本BMD明显高于空白对照组，差异有统计学意义（P〈0．01），8周时骨折区骨密度下降，低于正常胫骨平台：12周时较8周时增高接近正常胫骨平台。结论骨质疏松兔胫骨平台骨折填充硫酸钙骨水泥早期能增加骨密度，硫酸钙体内能够降解吸收，不干扰新骨的形成，能有效修复骨质疏松状态下的骨缺损。

Study in calcium sulfate bone cement for repairing tibial plateau fracture of osteoporosis rabbit

Objective To investigate the effect of the calcium sulfate on fracture repair activities. Methods Osteoporosis rabbit tibial plateau fracture model was estabilshed, filling with calcium sulfate as bone graft. The general observation, X-ray and bone mineral density （BMD） were analyzed. Results X-ray observations suggest that the calcium sulfate filled in the fracture zone was gradually absorpted and replaced by new bone tissue. The BMD of calcium sulfate in treated group after 1,2,3,4,6,8,12 week was significantly higher than those in the control group, the difference was statistically significant （P〈0.O1）. At 8 weeks, BMD of the fractures zone began to deerases. At 12 weeks, BMD increased compared with that of at 8 weeks, and it was equal to normal tibial plateau. Conclusion Osteoporosis rabbit tibial plateau fractures filled with calcium sulfate cement early can increase bone density, calcium sulfate can be degraded in vivo, do not interfere with the formation of new bone, can be an effective state of repairing the osteoporosis bone defect.