重叠综合征与慢性阻塞性肺疾病患者的日间肺功能变化差异

目的探讨重叠综合征患者与慢性阻塞性肺疾病（COPD）患者在日间肺功能上的变化差异。方法随机选择60例患者，将其分为二组，重叠综合征组30例，稳定期COPD组30例，两组患者的性别构成比、年龄和体重指数相匹配，无统计学差异（P〉0．05），所有患者均作静态肺功能检查及日间血气分析，并对各项相关指标进行统计学处理。结果重叠综合征组与稳定期COPD组患者的各项相关指标中，血气分析中两组二氧化碳分压（PaCO2）、氧分压（PaO2）及血氧饱和度（O2sat）无显著差异（P〉0．05）。静态肺功能中两组患者用力肺活量（FVC％）、1s用力呼气容积占预计值百分比（FEV1％）、FEV1／FVC％无显著差异（P〉0．05），而最大通气量（MVV％）、用力呼气峰流量（PEF％）、呼出25％肺容积时的最大呼气流量（FEF25％）低于稳定期COPD组（P〈0．05）。结论重叠综合征患者与稳定期COPD患者的日间低氧血症差异不明显，但静态肺功能损害较严重。

Difference of daytime pulmonary function between overlap syndrome and chronic obstructive pulmonary disease patients

Objective To explore the difference of daytime pulmonary function between overlap syndrome and chronic obstructive pulmonary disease （COPD） patients. Methods 60 patients were divided into two groups randomly, which contained 30 overlap syndrome patients and 30 stable COPD patients respectively. There were no statistical differences in the age, sex constituent ratio and body mass index between the two groups （P 〉 0.05）. All the 60 patients were monitored for pulmonary function tests and blood gas analysis in the daytime. The results were analyzed statistically. Results The arterial partial pressure of carbon dioxide （PaCO2 ） , partial pressure of oxygen （PaO2 ）and oxygen saturation（ O2 sat）in the two groups were similar （P 〉 0.05 ）. The pulmonary function test showed that the forced vital capacity （ FVC）, forced expiratory volume in Is of predicted（ FEV1% ）and FEV1/FVC% were similar （P 〉 0.05）, but maximum ventilatory volume （MVV）, peak expiratory flow （PEF）, and forced expiratory flow 25 % （FEF25 % ）in overlap syndrome group were significantly lower than that in the stable COPD group （ P 〈 0. 05 ）. Conclusions Daytime hypoxemia in the two groups is similar, but the pulmonary function injury is more serious than that in stable COPD group.