三维适形放疗同期联合GP方案治疗晚期非小细胞肺癌临床分析

目的评价三维适形放疗同期联合同步GP方案治疗局部晚期非小细胞肺癌的疗效及毒副反应。方法对资料完整的168例晚期非小细胞肺癌患者进行回顾性研究,其中单纯放疗83例,同步放化疗85例。放疗采用直线加速器6MV、15MV X线,剂量60～66gy/33次/7周。化疗采用吉西他滨(益非)+顺铂,在放疗第一周和第四周进行。结果随访3年。单纯放疗组1、3年生存率分别为62.7%和30.1%,放化疗组1、3年生存率分别为80%和40.7%。两组有显著差异P<0.01。结论晚期非小细胞肺癌同步放化疗可以提高局部控制率、提高生存率。两组毒副作用无显著差异。

Clinical analysis of three dimensional conformal radiotherapy combined synchronous GP regimen in the treatment of locally advanced non small cell lung cancer

Objective To evaluate the three dimensional conformal radiotherapy combined synchronous GP scheme treatment from locally advanced non-small cell lung cancer effect and side-effect.Methods Data of the whole 168 patients with terminal NSCLC were retrospected,of which only 83 cases got radiation therapy,the chemoradiation was 85 cases.Radiation therapy USES the straight line accelerator 6 MV,15 MV X-ray,dose 60-66 gy / 33 times / 7 weeks.Chemotherapy using gemcitabine plus cisplatin,in the first week and around the radiotherapy.Results By 3 years of follow-up,survival rates of pure radiation therapy group were 62.7% and 30.1% respectively,radiation and chemotherapy group were 80% and 40.7% respectively.Two groups were significantly different P<0.01.Conclusions Advanced non-small-cell lung cancer chemoradiation can improve local control,improve survival.Side effects in two groups have no significant differences.