| 长期服用氢氯噻嗪后RAAS活性变化与血糖变化关系 |
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| 引用本文： | 杨鹏,李云,吴寿岭,王丽晔,刘秀荣,赵丹丹,武英,陈锐,李发飞. 长期服用氢氯噻嗪后RAAS活性变化与血糖变化关系[J]. 中国药房, 2010, 0(16): 1484-1487 |
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| 作者姓名： | 杨鹏 李云 吴寿岭 王丽晔 刘秀荣 赵丹丹 武英 陈锐 李发飞 |
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| 作者单位： | 华北煤炭医学院附属医院神经外科;华北煤炭医学院预防医学教研室;华北煤炭医学院附属开滦医院心内科; |
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| 摘 要： | 目的:探讨长期服用氢氯噻嗪(HCTZ)后肾素-血管紧张素-醛固酮系统(RAAS)活性变化与血糖(GLU)变化之间的关系。方法:选择119例高血压患者,测定基线RAAS活性和GLU水平等指标后,给予HCTZ12.5mg,qd,1年后测定RAAS活性和GLU水平,分析服用HCTZ1年后RAAS活性变化与GLU水平之间的关系。结果:服用HCTZ1年后,血清肾素活性(PRA)水平升高组与不升高组患者GLU水平下降幅度分别是(-0.26±0.26)mmol·L-1、(-1.36±0.23)mmol·L-1,差异有统计学意义(P<0.05);血清血管紧张素Ⅱ(AngⅡ)水平升高组与不升高组患者GLU水平下降幅度分别是(-0.17±0.18)mmol·L-1、(-1.07±0.21)mmol·L-1,差异有统计学意义(P<0.05)。服药后AngⅡ水平升高的患者中,GLU水平同时也升高的人数比例(40.5%)明显高于AngⅡ水平不升高患者中的相应患者比例(16.9%),差异有统计学意义(P<0.05)。校正年龄、性别、基线GLU水平等其他因素影响后,服用HCTZ1年后的血清AngⅡ水平变化与GLU水平变化独立相关。结论:服用HCTZ1年后的RAAS活性变化与GLU变化之间存在相关关系。
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| 关 键 词： | 肾素-血管紧张素-醛固酮系统 噻嗪类利尿剂 血管紧张素Ⅱ 血糖 |
Relationship of the Change of RAAS Activity with Plasma Glucose after Long Term Therapy of Hydrochlorothiazide |
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| YANG Peng LI Yun,ZHAO Dan-dan,WU Ying,CHEN Rui,LI Fa-fei WU Shou-ling,WANG Li-ye,LIU Xiu-rong. Relationship of the Change of RAAS Activity with Plasma Glucose after Long Term Therapy of Hydrochlorothiazide[J]. China Pharmacy, 2010, 0(16): 1484-1487 |
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| Authors: | YANG Peng LI Yun ZHAO Dan-dan WU Ying CHEN Rui LI Fa-fei WU Shou-ling WANG Li-ye LIU Xiu-rong |
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| Affiliation: | YANG Peng(Department of Neurosurgery,The Affiliated Hospital of North China Coal Medical College,Tang-shan 063000,China) LI Yun,ZHAO Dan-dan,WU Ying,CHEN Rui,LI Fa-fei(Dept. of Preventive Medicine,North China Coal Medical College,Tangshan 063000,China) WU Shou-ling,WANG Li-ye,LIU Xiu-rong(Dept. of Cardiology,Kailuan Hospital of North China Coal Medical College,China) |
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| Abstract: | OBJECTIVE:To investigate the relationship between the change of RAAS activity and plasma glucose after one year therapy of hydrochlorothiazide. METHODS:A total of 119 hypertensive patients were enrolled in this study. The activity of RAAS and plasma glucose level were measured at baseline. Patients were given 12.5 mg hydrochlorothiazide once a day for one year. Then the relationship between activity change of RAAS and the level of plasma glucose were analyzed. RESULTS:After one year treatment,the decrease o... |
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| Keywords: | Renin-angiotensin-aldostetone system Thiazide diuretic Angiotensin Ⅱ Plasma glucose |
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