| 苦参碱对人增生性瘢痕成纤维细胞超微结构的影响 |
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| 引用本文： | 汤苏阳,黄高升,蔡宝仁. 苦参碱对人增生性瘢痕成纤维细胞超微结构的影响[J]. 中国美容医学, 2001, 10(2): 100-102 |
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| 作者姓名： | 汤苏阳 黄高升 蔡宝仁 |
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| 作者单位： | 1. 第四军大学病理教研室
2. 沈阳军区205医院 |
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| 摘 要： | 目的：研究苦参碱（Matrine,Mat)对人增生性瘢痕成纤维细胞超微结构的影响。方法：将Mat作用于体外培养的增生性瘢痕成纤维细胞，利用透视电镜、扫描电镜观察细胞的形态变化。结果：Mat可使增生性瘢痕成纤维细胞的超微结构的发生变化；细胞内粗面质网减少，核糖体有部分脱粒，解聚现象，溶解体酶，核染色质浓缩集聚至核膜周边，出现凋亡早期的改变，细胞外表面较用药前光滑，合成分泌的基质明显减少，结论：Mat在体外能明显抑制增生性瘢痕成纤维细胞的功能并引起其超微结构发生改变。
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| 关 键 词： | 苦参碱 增生性瘢痕 成纤维细胞 超微结构 |
| 文章编号： | 1008--6455(2001)02-0100-03 |
| 修稿时间： | 2000-10-24 |
THE FIBROBLASTIC ULTRASTRUCTURE INFLUENCE OF MATRINE ON HYPERTROPHIC SCAR |
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| TANG Su-yang,HUANG Gao-sheng,CAI Bao-ren. THE FIBROBLASTIC ULTRASTRUCTURE INFLUENCE OF MATRINE ON HYPERTROPHIC SCAR[J]. Chinese Journal of Aesthetic Medicine, 2001, 10(2): 100-102 |
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| Authors: | TANG Su-yang HUANG Gao-sheng CAI Bao-ren |
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| Affiliation: | Xi'an 710032 |
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| Abstract: | Objective:To investigate the influence of fibroblastic ultrastructure after applying the matrine on the hypertrohic scar. Methods:The fibroblasts were cultured in vitro,to observe the morphology changes of cell by Electron microscopy(SEM and TEM)after applying matrine. Results:Compared with the untreated fibroblast from hypertrophic scar, the rough endoplasmic reticulums were decreased,the ribosome were appeared degranulation and depolymerization and lysosomes were increased respectively. The nuclear chromations were condensed to gather to the side of nuclear membranes. Conclusion:Mat could inhibit the function of hypertrophic fibroblasts and induce the apoptosis of hypertrophic fibroblasts and changed the ultrastructural significantly. [ |
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| Keywords: | Matrine Hypertrophic scar Fibroblast Ultrastructure |
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