Effect of pyridine and quinoline N-oxides on microsomal Na,K-ATPase activity

Some heteroaromatic N-oxides of pyridine and quinoline derivatives at concentrations ranging from 10⁻⁴ to 10⁻¹⁰ mole/liter inhibit Na,K-ATPase activity in cattle brain microsomes stronger than does strophanthin K (a drug used for the treatment of cardiac insufficiency). A new Na,K-ATPase activator, 2-(2,4-dimethoxystyryl)quinoline-N-oxide), has been found, which is capable of acting at concentrations within 10⁻⁶–10⁻⁹ mole/liter. Since these compounds activate the enzyme in very low concentrations, they can probably be effective for the treatment of some disorders involving violation of the Na,K-ATPase function. __________ Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 7, pp. 3–4, July, 2006.