Colonic adenomas: Stereology and growth mechanisms |
| |
| Authors: | Hans Elias PhD Dr Dallas M Hyde PhD Ronald S Mullens BS Frederick C Lambert BS |
| |
| Institution: | (1) Department of Pediatrics and Pathology, University of California, San Francisco, California;(2) Department of Biology, City College of San Francisco, San Francisco, California;(3) Department of Anatomy, School of Veterinary Medicine, University of California, 95616 Davis, California |
| |
| Abstract: | Stereologic methods were used to determine the amount of growth of colonic adenomatous polyps. Epithelial surfaces were increased
from 12 to 226 times compared with the normal mucosa of origin, including the epithelium of the crypts. The number of cells
was increased from 12 to 370 times. The supposed villi of the polyps are in reality branched folia, and the crypts between
them are slit-like, permitting flow of ingesta through them. The increase in the number of cells is not primarily dependent
on mitotic activity but more on amitotic nuclear fragmentation
Supported in part by NIH grant AM 19172. |
| |
| Keywords: | Adenoma Colon Electron Microscopy Neoplasm Polyp Stereologyl |
| 本文献已被 SpringerLink 等数据库收录！ |
|
