| 扶脾益胃方治疗大肠癌术后化疗患者的近期疗效及其对免疫功能的影响 |
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| 引用本文： | 吴国琳,余国友,李剑平,熊福林. 扶脾益胃方治疗大肠癌术后化疗患者的近期疗效及其对免疫功能的影响[J]. 中国中药杂志, 2010, 35(6): 782-785 |
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| 作者姓名： | 吴国琳 余国友 李剑平 熊福林 |
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| 作者单位： | 浙江大学医学院附属第一医院,浙江杭州,310003 |
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| 基金项目： | 浙江省中医药管理局项目( 2005C075) |
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| 摘 要： | 目的:观察中药扶脾益胃方治疗大肠癌术后化疗患者的近期临床疗效,并探讨其对患者免疫功能的影响。方法:58例大肠癌术后化疗患者随机分为中药组(33例)和对照组(25例),观察化疗期间不良反应、卡氏(Karnofsky)评分以及近期临床疗效,在治疗前后检测T细胞亚群(CD3+,CD4+,CD8+细胞)和NK细胞的百分比,同时将28例健康成年人做为正常对照组(正常组)。结果:化疗12个周期后中药组近期疗效优于对照组,但无明显差异,而中药组病人生活质量明显优于对照组(P0.05),化疗不良反应的发生低于对照组(P0.05),化疗前所有患者外周血CD3+,CD4+T细胞下降、CD8+T细胞升高、NK细胞活性下降。治疗后患者外周血CD3+T细胞和NK细胞增高,但仍低于正常组,CD8+T细胞降低但高于正常组,均无显著性差异,中药组CD4+T细胞升高,与对照组和正常组相比有显著性差异(P0.05)。结论:扶脾益胃中药能有效防治大肠癌术后化疗不良反应,同时能改善患者的生活质量和免疫功能,提高化疗效果。
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| 关 键 词： | 大肠癌 化疗/副反应 扶脾益胃中药 近期疗效 T细胞亚群 |
| 收稿时间： | 2009-12-12 |
Short term therapeutic effect on treatment of postoperational largeintestine carcinoma by Fupiyiwei decoction combined with chemotherapyand it's effect on immune fuction |
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| WU Guolin,YU Guoyou,LI Jianping and XIONG Fulin. Short term therapeutic effect on treatment of postoperational largeintestine carcinoma by Fupiyiwei decoction combined with chemotherapyand it's effect on immune fuction[J]. China Journal of Chinese Materia Medica, 2010, 35(6): 782-785 |
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| Authors: | WU Guolin YU Guoyou LI Jianping XIONG Fulin |
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| Affiliation: | First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China;First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China;First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China;First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China |
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| Abstract: | Objective: To investigate short term clinical therapeutic effect of fupiyiwei decoction(FPYWD) combined with chemotherapy in treating postoperational large intestine carcinoma and the effect on immune function.Method: The 58 cases of postoperational large intestine carcinoma were randomly divided into the traditional Chinese medicine(TCM) group(33 cases) and the control group(25 cases).The toxic and adverse reaction,Karnofsky score and clinical therapeutic effect during chemotherapy were observed,and the le... |
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| Keywords: | large intestine carcinoma chemotherapy/adverse reaction traditional Chinese medicine of fupiyiwei short term clinical therapeutic T lymphocyte subsets |
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