| 雌激素对血管平滑肌细胞凋亡的影响 |
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| 引用本文： | 和庆余,张英,王淑秋,王柏欣,张波,高艳华,刘程伟.雌激素对血管平滑肌细胞凋亡的影响[J].黑龙江医药科学,2003,26(5):16-16,17. |
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| 作者姓名： | 和庆余 张英 王淑秋 王柏欣 张波 高艳华 刘程伟 |
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| 作者单位： | 佳木斯大学基础医学院,黑龙江,佳木斯,154007 |
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| 基金项目： | 黑龙江省自然科学基金资助项目 |
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| 摘 要： | 目的 :观察雌激素对血管平滑肌细胞 (SMC)凋亡的影响。方法 :以大鼠为对象 ,观察正常对照组、去卵巢组及去卵巢 +雌二醇治疗组大鼠血管平滑肌细胞凋亡的关系。结果 :雌二醇治疗组血管平滑肌细胞凋亡较去卵巢组相比明显减少(P>0 .0 5 ) ,与正常对照组比较差别无显著性意义 (P >0 .0 5 )。结论 :雌二醇对血管平滑肌细胞的凋亡有抑制作用 ,可能是其预防动脉粥样硬化的机制
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| 关 键 词： | 雌激素 血管 平滑肌细胞 细胞凋亡 |
| 文章编号： | 1008-0104(2003)05-0016-01 |
The effect of estrogen on apoptosis of vascular smooth muscle cells |
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| HE Qing-yu,ZHANG Ying,WANG Shu-qiu,WANG Bai-xin,ZHANG Bo,GAO Yan-hua,LIU Cheng-wei.The effect of estrogen on apoptosis of vascular smooth muscle cells[J].Heilongjiang Medicine and Pharmacy,2003,26(5):16-16,17. |
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| Authors: | HE Qing-yu ZHANG Ying WANG Shu-qiu WANG Bai-xin ZHANG Bo GAO Yan-hua LIU Cheng-wei |
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| Abstract: | Objective: To determine the effect of estrogen on apoptosis of vascular smooth muscle cells (VSMCs). Methods: Wistar rats were randomly divided into three groups: in group A,rats were sham-ovariectomized;in group B, rats were ovariectomized;in group C,rats were ovariectomized by estrogen replacement therapy. Rats were killed after 1 month.Apoptosis of VSMCs was determined. Results:In groupC, the apoptosis of vascular smooth muscle cells was decreased rapidly(P<0.05), similar to those in group A(P>0.05).Conclusion: Estrogen inhibits apoptosis of vascular smooth muscle cells. |
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| Keywords: | estrogen vascular smooth muscle cells apoptosis |
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