PET和PET/CT在头颈癌中的应用

正电子发射断层扫描（PET）是一种功能性显像设备，是目前唯一可以了解组织分子生物学代谢改变的影像技术，临床研究已经证实其在恶性肿瘤的诊治中显示出了独特价值；但是由于PET缺乏解剖定位，临床应用仍受到一定限制；而PET／CT具有PET和CT的2种功能，实现了分子影像与解剖影像的同机融合，双方信息互补，彼此印证，进一步提高了诊断的特异性和准确性，自应用以来，受到学者们的普遍关注。本文就PET和PET／CT特别是PET／CT在头颈癌中的应用作一综述。

Application of PET and PET/CT in head and neck cancers

Positron emission tomography(PET), a functional imaging device, can track biological and metabolic changes caused by therapy or by disease progression, and therefore play a significant role in the management of cancers used as a clinical imaging modality. Although PET facilitates the evaluation of metabolic characteristics of a wide variety of cancers, it is limited in its ability to visualize anatomical structures. PET/CT fulfills fusion of PET and CT imaging, so it can provide metabolic informations of disease with anatomical finding, adding further information to the diagnoses; It makes the location and characterization of the lesions more accurate. This paper reviews the application of PET and PET/CT in head and neck cancers. Supported by National Natural Science Foundation of China (Grant No.30471898),Key Project of Science and Technology Commission of Shanghai Municipality (Grant No.03JC14052) and Shanghai Leading Academic Discipline Project (Grant No.Y0203).