| 五氟苯甲酸的制备 |
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| 引用本文： | 葛雅莉,林原斌,苏琼,尹建湘,赵辉. 五氟苯甲酸的制备[J]. 中国医药工业杂志, 2007, 38(1): 14-14,21 |
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| 作者姓名： | 葛雅莉 林原斌 苏琼 尹建湘 赵辉 |
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| 作者单位： | 湘潭大学化学学院,湖南,湘潭,411105 |
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| 摘 要： | 五氯苄腈与活化的氟化钾在环丁砜中进行氟交换制得五氟苄腈，再经50％硫酸水解得到司帕沙星等氟喹诺酮类抗菌药原料五氟苯甲酸，总收率约45％。
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| 关 键 词： | 五氟苯甲酸 中间体 制备 |
| 文章编号： | 1001-8255（2007）01-0014-01 |
| 修稿时间： | 2006-10-09 |
Preparation of 2,3,4,5,6-Pentafluorobenzoic Acid |
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| GE Ya-li,LIN Yuan-bin,SU Qiong,YIN Jian-xiang,ZHAO Hui. Preparation of 2,3,4,5,6-Pentafluorobenzoic Acid[J]. , 2007, 38(1): 14-14,21 |
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| Authors: | GE Ya-li LIN Yuan-bin SU Qiong YIN Jian-xiang ZHAO Hui |
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| Affiliation: | College of Chemistry, Xiangtan University, Xiangtan 411105 |
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| Abstract: | 2,3,4,5,6-Pentafluorobenzoic acid was synthesized from 2,3,4,5,6-pentachlorobenzonitrile by fluorine exchange in sulfolane to give 2,3,4,5,6-pentafluorobenzonitrile, which was subjected to hydrolysis by 50% sulfuric acid with an overall yield of about 45 %. |
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| Keywords: | 2,3,4,5,6-pentafluorobenzoic acid intermediate preparation |
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