沙参提取物镇咳祛痰及免疫增强作用研究

目的：以沙参提取物作为受试物,观察其镇咳祛痰作用及对免疫功能的影响。方法：采用豚鼠枸橼酸引咳法、小鼠酚红排泌试验法观察沙镇咳祛痰作用;采用碳粒廓清法和二硝基氟诱导小鼠迟发型变态反应试验法,观察沙参对非特异性免疫功能和特异性细胞免疫功能的影响。结果：结果显示沙参乙醇和乙酸乙酯提取物对豚鼠枸橼酸引咳具有显著的对抗作用,乙酸酯提取并有显著地促进小鼠酚红排泌作用。沙参多糖及水提取物能显著地增加碳 粒清指数

Studies of Radix adenophorae extracts on antitussive-expectorant and immunoenhancement effects

OBJECTIVETo evaluate the immunomodulating,antitussive an d expectorant effects of Radix Adenophorae extracts.METHODSCough mo del was induced by citric acid in guinea pig,and phenol red expectoration test. Carbon clearance test and dinitrofluorobenzene-induced delayed type hypersensit ivity test(DTH) were used.RESULTSThe tests showed that ethanol extr act and ethyl acetate extract had significant antitussive effect on guinea pig i nduced by citric acid,ethyl acetate extract also had expectorant effect.Polysacc haride and water extract could increase the index of K and α in carbon clearanc e test.Enhancement of ear swelling was also found,showing that radix adenophorae could increase delayed type hypersensitivity induced by DNFB.Polysaccharide inc reased the weight of spleen and thymus,but water extract only increased the weig ht of thymus.CONCLUSIONRadix Adenophorae extracts had significant a ntitussive and expectant effects,and could greatly enhance immunological functio n.