Prevalence of coeliac disease in Turner syndrome |
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Authors: | S-A Ivarsson A Carlsson A Bredberg J Alm S Aronsson J Gustafsson L Hagenäs A Häger B Kriström C Marcus C Moëll KO Nilsson T Tuvemo O Westphal K Albertsson-Wikland J Aman |
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Institution: | Department of Paediatrics, University of Lund, University Hospital, Malm?, Sweden. |
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Abstract: | This study was undertaken to investigate the prevalence of coeliac disease in children and adolescents with Turner syndrome. Eighty-seven children and adolescents with Turner syndrome were screened for IgA-antiendomysium antibodies (EMA) and IgA-antigliadin antibodies (AGA), 5% (4/87) being found to be EMA-positive, and 15% (13/87) to have AGA levels above normal. Of the 10 patients who were either AGA- or EMA-positive and further investigated with intestinal biopsy, four manifested villous atrophy (i.e. all three of the EMA-positive patients, but only one of the seven AGA-positive patients). The results suggest EMA-positivity to be a good immunological marker for use in screening for coeliac disease, and such screening to be justified in patients with Turner syndrome. |
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