Gene expression changes associated with Barrett's esophagus and Barrett's-associated adenocarcinoma cell lines after acid or bile salt exposure |
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| Authors: | Ying Hao Sumita Sood George Triadafilopoulos Jong Hyeok Kim Zheng Wang Peyman Sahbaie M Bishr Omary Anson W Lowe |
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| Affiliation: | (1) Department of Medicine, Stanford University, Stanford, CA, USA;(2) Stanford University Digestive Disease Center, Stanford, CA, USA;(3) Gastroenterology Section, Palo Alto Veterans Affairs Health Care System, Palo Alto, CA, USA |
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| Abstract: | Background Esophageal reflux and Barrett's esophagus represent two major risk factors for the development of esophageal adenocarcinoma. Previous studies have shown that brief exposure of the Barrett's-associated adenocarcinoma cell line, SEG-1, or primary cultures of Barrett's esophageal tissues to acid or bile results in changes consistent with cell proliferation. In this study, we determined whether similar exposure to acid or bile salts results in gene expression changes that provide insights into malignant transformation. |
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