CD39 activity correlates with stage and inhibits platelet reactivity in chronic lymphocytic leukemia |
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| Authors: | Dianne Pulte Kim E Olson M Johan Broekman Naziba Islam Harold S Ballard Richard R Furman Ashley E Olson Aaron J Marcus |
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| Affiliation: | (1) Research Service, Veterans Affairs New York Harbor Healthcare System, New York, NY 10010, USA;(2) Medicine-Hematology/Oncology, Weill Medical College Cornell University, New York, NY 10021, USA;(3) Medical Service, VA NY Harbor Healtcare System, New York, NY 10010, USA;(4) Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA |
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| Abstract: | Background Chronic lymphocytic leukemia (CLL) is characterized by accumulation of mature appearing lymphocytes and is rarely complicated by thrombosis. One possible explanation for the paucity of thrombotic events in these patients may be the presence of the ecto-nucleotidase CD39/NTDPase-1 on the surface of the malignant cells in CLL. CD39 is the major promoter of platelet inhibition in vivo via its metabolism of ADP to AMP. We hypothesize that if CD39 is observed on CLL cells, then patients with CLL may be relatively protected against platelet aggregation and recruitment and that CD39 may have other effects on CLL, including modulation of the disease, via its metabolism of ATP. |
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