Oral urea in the treatment of colo-rectal liver metastases

A consecutive series of 10 patients with hepatic metastases from colo-rectal carcinoma have been treated with oral urea. This substance has been reported to produce regression of hepatic secondaries from a variety of primary sources including colon. Although well tolerated, and leading to subjective improvement in some patients, no objective benefit has been confirmed from the treatment in this study.