| p27蛋白在子宫内膜癌的表达及意义 |
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| 引用本文： | 生秀杰,刘风华,张梅英,王沂峰.p27蛋白在子宫内膜癌的表达及意义[J].四川肿瘤防治,2006,19(3):170-171. |
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| 作者姓名： | 生秀杰 刘风华 张梅英 王沂峰 |
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| 作者单位： | 广州市第二人民医院妇产科研究所 广东广州510150(生秀杰，刘风华，王沂峰)，中国医科大学实验动物部 辽宁沈阳110001(张梅英) |
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| 摘 要： | 目的:探讨p27蛋白在子宫内膜癌的表达及意义。方法:应用免疫组化,检测12例增生期子宫内膜,10例子宫内膜非典型增生及42例子宫内膜样腺癌标本中p27蛋白的表达。结果:p27蛋白在增生期子宫内膜、子宫内膜非典型增生及子宫内膜癌中的阳性表达率逐渐降低,分别为100%、60%和40.47%。随子宫内膜癌临床分期的升高、病理分级的降低及肌层浸润的加深,p27蛋白的表达呈逐渐降低的趋势。结论:p27蛋白低表达可能与子宫内膜癌的不良预后有关。
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| 关 键 词： | 子宫内膜癌 p27蛋白 免疫组织化学 |
| 文章编号： | 1007-0281（2006）03-0170-02 |
| 收稿时间： | 2006-02-27 |
| 修稿时间： | 2006年2月27日 |
Expression of p27 Protein in Endometrial Carcinoma |
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| SHENG Xiu-jie, LIU Feng-hua , ZHANG Mei-ying, et al.Expression of p27 Protein in Endometrial Carcinoma[J].Sichuan Journal of Cancer Control,2006,19(3):170-171. |
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| Authors: | SHENG Xiu-jie LIU Feng-hua ZHANG Mei-ying |
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| Abstract: | Objective: To study the expression of p27 protein and the significance in human endometrial carcinoma.Methods: Immunohistochemical staining was used to detect the expression of p27 protein in carcinomatous tissues of 42 patients with endometrial carcinoma,10 cases with atypical hyperplasia and 12 normal endometrium tissues.Results: The positive expression of p27 was reduced gradually in the normal endometrium,atypical hyperplasia and endometrial carcinoma(100%,60% and 40.47%,respectively).In endometrial carcinoma,with progression of clinical stage,decreasing of histological grade and deepening of cancer invasion,the expression of p27 decreased.Conclusion: The low expression of p27 protein in endometrial carcinoma may have relationship with bad prognosis. |
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| Keywords: | Endometrial Carcinoma p27 Immunohistochemistry |
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