Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax |
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Authors: | Storti-Melo Luciane Moreno da Costa Daniela Reis Souza-Neiras Wanessa Christina Cassiano Gustavo Capatti Couto Vanja Suely Calvosa D'Almeida Póvoa Marinete Marins Soares Irene da Silva de Carvalho Luzia Helena Arevalo-Herrera Myrian Herrera Sócrates Rossit Andrea Regina Baptista Cordeiro José Antonio de Mattos Luiz Carlos Machado Ricardo Luiz Dantas |
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Affiliation: | Departamento de Biociências, Campus Universitário Prof. Alberto Carvalho, Universidade Federal de Sergipe, Itabaiana, SE, Brazil. stortilu@yahoo.com.br |
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Abstract: | We evaluated the influence of allelic frequency of the human leukocyte antigen (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite and merozoite peptides in patients with Plasmodium vivax malaria acquired in endemic areas of Brazil. IgG antibodies were detected by enzyme-linked immunosorbent assay against four peptides of circumsporozoite protein (CSP) (amino, carboxyl, and VK210 and VK247 repeats) and peptides of merozoite surface protein 1 (MSP-1), apical membrane antigen 1 (AMA-1), and Duffy-binding protein (DBP). We found an association between HLA-DR3 and HLA-DR5 alleles and lack of antibody response to CSP amino terminal, as well as an association between HLA-DR3 and the highest antibody response to MSP1 (Pv200L). In conclusion, we suggest a potential regulatory role of the HLA-DRB1 alleles in the production of antibodies to a conserved region of P. vivax CSP and MSP1 in Brazilian population exposed to malaria. |
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