| 结缔组织生长因子在肾间质纤维化中的表达及其调控 |
| |
| 引用本文： | 刘燕,樊均明. 结缔组织生长因子在肾间质纤维化中的表达及其调控[J]. 中国病理生理杂志, 2004, 20(9): 1725-1728 |
| |
| 作者姓名： | 刘燕 樊均明 |
| |
| 作者单位： | 四川大学华西医院肾内科，四川 成都610041 |
| |
| 基金项目： | 国家自然科学基金资助项目(No.30170437) |
| |
| 摘 要： | CTGF, a member of the CCN family of immediate early genes, is a recently discovered profibrotic growth factor, which is involved in many pathophysiologic procedures. CTGF acts as a downstreame ffector of TGF-β acting on interstitial ceils to enhance the progression of fibrotic renal diseases. It has been shown that CTGF gene expression can be induced or blocked by some kinds of cytokine and drugs. It is an interesting candidate target for future intervention strategies of renal interstitial fibrosis.
|
| 关 键 词： | 结缔组织生长因子 转化生长因子β 肾间质纤维化 |
| 文章编号： | 1000-4718(2004)09-1725-04 |
| 收稿时间： | 2002-12-31 |
| 修稿时间： | 2003-05-05 |
Expression and modulation of connective tissue growth factor in renal interstitial fibrosis |
| |
| LIU Yan,FAN Jun-ming. Expression and modulation of connective tissue growth factor in renal interstitial fibrosis[J]. Chinese Journal of Pathophysiology, 2004, 20(9): 1725-1728 |
| |
| Authors: | LIU Yan FAN Jun-ming |
| |
| Affiliation: | Department of Nephropathy, West China Hospital of Sichuan University, Chengdu 610041, China |
| |
| Abstract: | CTGF, a member of the CCN family of immediate early genes, is a recently discovered profibrotic growth factor, which is involved in many pathophysiologic procedures. CTGF acts as a downstream effector of TGF-β acting on interstitial cells to enhance the progression of fibrotic renal diseases. It has been shown that CTGF gene expression can be induced or blocked by some kinds of cytokine and drugs. It is an interesting candidate target for future intervention strategies of renal interstitial fibrosis. |
| |
| Keywords: | Connective tissue growth factor Transforming growth factor-β Renal interstitial fibrosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《中国病理生理杂志》浏览原始摘要信息 |
|
点击此处可从《中国病理生理杂志》下载全文 |
