5-HT(1B) receptors play a prominent role in the proliferation of T-lymphocytes |
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Authors: | Yin Jun Albert Ross H Tretiakova Anna P Jameson Bradford A |
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Affiliation: | Department of Biochemistry and Molecular Biology at Drexel University College of Medicine, Philadelphia, PA, USA. |
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Abstract: | Serotonin plays a role in T cell activation, but there is no clear consensus of which of the 14 serotonergic receptors control this activations pathway. We have used a broad range of serotonergic receptor antagonists to define the functional involvement of these receptors governing the proliferation of primary T cells as well as in T cell lines. Our data shows that antagonism of the 5-HT(1B) receptor inhibits the proliferation of both human and murine primary helper T cells and of human helper T cell lines. As a whole, our data suggest that other serotonergic receptors may contribute to the proliferative signals, but the 5-HT(1B) receptor plays the most dominant role. |
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