| 脂质过氧化反应在脊髓损伤中的作用 |
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| 引用本文： | 王季安,潘晓勤,郭梅,胡明昌,蔡毅,陈士垣. 脂质过氧化反应在脊髓损伤中的作用[J]. 南京医科大学学报(自然科学版), 1992, 0(3) |
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| 作者姓名： | 王季安 潘晓勤 郭梅 胡明昌 蔡毅 陈士垣 |
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| 作者单位： | 南京医学院儿科研究室，南京医学院儿科研究室，南京医学院儿科研究室，南京医学院第二附属医院，南京医学院第二附属医院，南京医学院第二附属医院 |
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| 摘 要： | 本实验通过大鼠脊髓损伤模型,观察了抗氧化剂对组织和血清丙二醛(MDA)的影响。结果表明:大鼠脊髓损伤2h 后,损伤组织中 MDA 含量已明显高于对照组(P<0.05),3d 后增高更著(P<0.01);血清 MDA 在损伤2h 后已极明显高于对照组(P<0.01),以后逐渐降低。维生素 E、超氧化物歧化酶、过氧化氢酶及二甲基亚砜均能显著降低损伤组织 MDA(P<0.01)和血清 MDA(P<0.05)。提示脊髓损伤后组织脂质过氧化反应增强,早期应用抗氧化剂,可作为减轻继发损害的一项有效治疗。
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| 关 键 词： | 脊髓损伤 脂质过氧化反应 抗氧化剂 大鼠 |
Effect of Lipid Peroxidation on Spinal Cord Injury in Rats |
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| Wang Ji''''an Laboratory of Pediatric Reaearch Hu Mingchang The Second Affiliated Hospital. Effect of Lipid Peroxidation on Spinal Cord Injury in Rats[J]. Acta Universitatis Medicinalis Nanjing, 1992, 0(3) |
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| Authors: | Wang Ji''''an Laboratory of Pediatric Reaearch Hu Mingchang The Second Affiliated Hospital |
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| Affiliation: | Wang Ji'an Laboratory of Pediatric Reaearch Hu Mingchang The Second Affiliated Hospital |
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| Abstract: | The effect of antioxidants on the malondialdehyde(MDA)in serum and spinal cord of rats was observed with rats'model of spinal cord injury.The data showed that the level of MDA in damaged tissue was increased as compared with that in control(P less than 0.05)in 2 hours after spinal cord injury,and increased further in 3 days.In the meanwhile,serum MDA of rats wish damaged spinal cord was significantly higher than that of control,and decreased latter.The results also revealed that vitamin E,superoxide dismutase catalase and dimethyl sulfoxide could markedly decrease the level of MDA in serum and spinal cord of rats with spinal cord injury.These results suggest that there must be increased lipid peroxidation in injuried spinal cord,and early administration of antioxidants may ameliorate the secondary injury of spinal cord. |
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| Keywords: | lipid peroxidation spinal cord injury antioxidant rats |
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