Cell death-inducing effect of novel palladium(II) and platinum(II) complexes on non-small cell lung cancer cells in vitro |
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| Authors: | Engin Ulukaya Ferda Ari Konstantinos Dimas Mehmet Sarimahmut Emel Guney Nikos Sakellaridis Veysel T Yilmaz |
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| Institution: | (1) Department of Clinical Biochemistry, Medical School, Uludag University, 16059 Bursa, Turkey;(2) Department of Biology, Faculty of Arts and Sciences, Uludag University, Bursa, Turkey;(3) Department of Pharmacology, School of Medicine, University of Thessaly, Biopolis, Larisa, Greece;(4) Department of Chemistry, Faculty of Arts and Sciences, Uludag University, Bursa, Turkey |
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| Abstract: | Purpose Treatment for lung cancer is still far from satisfying rates. Therefore, there is a need for novel anticancer agents. For
this purpose, novel platinum and palladium complexes {Pd(sac)(terpy)](sac)·4H2O (Complex 1), Pt(sac)(terpy)](sac)·5H2O (Complex 2), PdCl(terpy)](sac)·2H2O (Complex 3), PtCl(terpy)](sac)·2H2O (Complex 4)} have been tested against three different non-small cell lung cancer cell lines (A549, H1299, PC-3). |
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