4种抗生素治疗细菌性上呼吸道感染的成本-效果分析

目的:评价治疗细菌性上呼吸道感染的4种抗生素药物的成本-效果。方法:将102例细菌性上呼吸道感染患者随机分为G1、G2、G3、G4组,分别给予琥乙红霉素分散片、罗红霉素胶囊、阿奇霉素分散片、克林霉素分散片治疗,疗程分别为10、10、5、10d,运用药物经济学方法进行成本-效果分析。结果:G1、G2、G3、G4组的成本分别为143.20、114.00、69.55、323.20元;有效率分别为88.89%、91.67%、91.30%、92.86%(P>0.05);成本-效果比分别为161.10、124.36、76.18、348.05;G1、G2、G4组相对于G3组增量成本-效果比分别为—3056.02、12013.51、16259.62,G1、G2、G4组的成本-效果比显著高于G3组(P<0.05)。结论:阿奇霉素分散片治疗方案较好。

Four Antibiotics in the Treatment of Upper Respiratory Tract Bacterial Infection:Cost-Effectiveness Analysis

OBJECTIVE: To evaluate the cost- effectiveness of four antibiotics in the treatment of bacterial upper respiratory tract infection. METHODS: A total of 102 patients with bacterial upper respiratory tract infection were randomly assigned to receive Erythromycin ethylsuccinate dispersible tablets for 10 days( Group 1) , roxithromycin capsules for 10 days ( Group 2) , azithromycin dispersible tablets for 5 days( Group 3) or klindamycin dispersible tablets for 10 days( Group 4) . The cost- effectiveness analysis was performed with pharmacoeconomic method. RESULTS: The costs of Groups 1, 2, 3 and 4 were 143. 20 yuan, 114. 00 yuan, 69. 55 yuan and 323. 20 yuan, respectively; the effective rates were 88. 89% , 91. 67% , 91. 30% and 92. 86% , respectively( P>0. 05) ; and the cost- effectiveness ratios were 161. 10, 124. 36, 76. 18 and 348. 05, respectively. The incremental cost- effectiveness ratios of Groups 1, 2 and 4 were — 3 056. 02, 12 013. 51 and 16 259. 62 respectively as compared with Group 3. The cost- effectiveness ratios of Groups 1, 2 and 4 were significantly higher as against Group 3( P<0. 05) . CON-CLUSION: Azithromycin dispersible tablet is the best one among the 4 groups.