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| 阿托伐他汀对心力衰竭患者心功能的影响 | |
| 引用本文： | 沈桂彬,张丽华. 阿托伐他汀对心力衰竭患者心功能的影响[J]. 临床医学, 2013, 33(8): 18-19 |
| 作者姓名： | 沈桂彬 张丽华 |
| 作者单位： | 沈桂彬 (郑州市第七人民医院,郑州,450016)； 张丽华 (郑州大学第二附属医院心血管内科)； |
| 摘 要： | 目的 观察阿托伐他汀对心力衰竭患者心功能的影响.方法 将66例心力衰竭患者随机分为对照组和治疗组（阿托伐他汀组）,在治疗前和治疗后2个月评价NHYA心功能,心脏彩超测定左室射血分数（LVEF）、左室舒张末期内径（LVEDD）,测定血浆N末端脑利钠肽（NT-proBNP） 及C-反应蛋白（CRP）水平.结果 与对照组治疗后相比,阿托伐他汀组NYHA心功能分级下降,NT-proBNP及CRP水平下降,LVEF增加及LVEDD降低.结论 阿托伐他汀通过抑制心脏重构、减轻炎症反应而对心力衰竭患者有益. |
| 关 键 词： | 阿托伐他汀 血浆N末端脑利钠肽 C-反应蛋白 心力衰竭 |
Effect of atorvastatin on cardiac function in patients with heart failure |
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| SHEN Gui-bin,ZHANG Li-hua. Effect of atorvastatin on cardiac function in patients with heart failure[J]. Clinical Medicine, 2013, 33(8): 18-19 | |
| Authors: | SHEN Gui-bin ZHANG Li-hua |
| Affiliation: | 1) The Seventh People’s Hospital of Zhengzhou,Zhengzhou 450016,China;2) Department of Cardiology,the Second Affiliated Hospital of Zhengzhou University |
| Abstract: | Objective To observe the effect of atorvastatin on cardiac function in patients with heart failure. Methods Six- ty-six patients with heart failure were randomly divided into control group and treatment group （atorvastatin group）, NHYA cardi- ac function, echocardiography determination of left ventricular ejection fraction （LVEF） , left ventricular end-diastolic diameter （LVEDD） were evaluated and plasma N-terminal brain natriuretic peptide （NT-proBNP） and C-reactive protein （CRP） levels were determined before treatment and two months after treatment. Results Compared with the control group after treatment, NY- HA cardiac function grade decline, NT-proBNP and CRP level decreased and LVEF increased and LVEDD reduction in treatment group. Conclusion Atorvastatin benefit patients with heart failure by reducing the inflammatory response and inhibiting cardiac remodeling. |
| Keywords: | Atorvastatin N-terminal brain natriuretic peptide C-reactive protein Heart failure |
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