炎症因子的变化在慢性阻塞性肺疾病病程发展中的应用探讨

目的观察炎症因子在慢性阻塞性肺疾病(COPD)稳定期、急性发作期的变化,探讨炎症因子对判断COPD病程进展的意义。方法本研究选取我院收治的90例COPD患者作为研究对象,同时选取同期我院体检的50例健康者作为对照组,分别对两组的血清CRP、IL-6、TNF-α、NO水平进行测定,比较COPD稳定期、急性发作期及健康者血清CRP、IL-6、TNF-α、NO的水平差异。结果 (1)COPD患者CRP、IL-6、TNF-α、NO的水平显著高于健康组(P<0.01);急性发作期患者CRP、TNF-α水平显著高于稳定期患者(P<0.01),具有统计学意义。(2)按照治疗期间肺功能状态分为a、b、c三点,a点CRP、IL-6、TNF-α、NO水平最高,b、c点依次降低,CRP、TNF-α、NO在不同时期中变化最为明显(P<0.05,P<0.01)。结论血清CRP、IL-6、TNF-α、NO水平在COPD患者显著增高,其中CRP、TNF-α、NO水平可作为评估COPD疾病进展的参考指标应用。

Application of change of inflammation factors in the progression of COPD course

Objective To observe the change of inflammatory factors in COPD patients at stable period and acute exacerbation stage, and to evaluate their significance on the judgment of progression of COPD course. Methods 90 COPD patients were selected as the study group, and 50 healthy people were taken as the control group. The levels of serum CRP, IL-6, TNF-α, and NO were measured and compared between the two groups. Results （ 1 ） The levels of CRP, IL-6, TNF-α, and NO were significantly higher in the study group than in the healthy controls （P 〈0. 01 ） , and the levels of CRP and TNF-α were obviously higher in the acute exacerbation group than in the stable group （P 〈0. 01 ）. （2） During the treatment, lung function was divided into a, b, and c throe points. The levels of CRP, IL- 6, TNF-α, and NO were the highest at the point a, and the difference of the levels of CRP, TNF-α, and NO was the most significant （P 〈 0. 01 ）. Conclusion The levels of serum CRP, IL-6, TNF-α, and NO increase obviously in COPD patients, and the levels of CRP, TNF-α, and NO earl be used as the reference indexes to assess the progression of COPD disease.