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| MDP-阿霉素脂质体的制备及其对大鼠成骨肉瘤的抗瘤作用 | |
| 引用本文： | 文艺,马保安,吴道澄,郝新宝,范清宇,徐海峰.MDP-阿霉素脂质体的制备及其对大鼠成骨肉瘤的抗瘤作用[J].第四军医大学学报,1999,20(12):S120-S122. |
| 作者姓名： | 文艺 马保安 吴道澄 郝新宝 范清宇 徐海峰 |
| 作者单位： | 1. 第四军医大学唐都医院全军骨肿瘤研究所,陕西西安,710038 2. 第四军医大学基础部化学教研室 3. 第四军医大学唐都医院核医学科 |
| 摘 要： | 目的：制备ＭＤＰ阿霉素脂质体，对ＳＤ大鼠ＵＭＲ１０６成骨肉瘤模型靶向治疗作用进行研究。方法：采用改良逆相蒸发法制备逆相蒸发脂质体，跨膜ＰＨ值梯度法包裹 阿霉素，经脂质体修饰后直接与ＭＤＰ交联；建立ＳＤ大鼠ＵＭＲ１０６成骨肉瘤模型，并观察ＭＤＰ－阿霉素脂质体对荷瘤鼠的掐瘤作用。结果：ＭＤＰ－阿霉素脂质体对荷瘤鼠的抑瘤作用。结果：ＭＤＰ－阿霉素脂质体其阿霉素包裹率为９２．３％，ＭＤＰ交联率为７０％，粒 |
| 关 键 词： | 阿霉素 脂质体 骨肉瘤 靶向作用 |
| 文章编号： | 1000-2790(1999)12-S120-S122 |
| 修稿时间： | 1999年9月30日 |
Preparation of adriamycin liposomes conjugated with MDP and its targeting action on Sprague-Dawley rat osteosarcoma tumor model in vivo |
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| WEN Yil,MA Bao-Anl,WU Dao-Cheng'''',HAOXin-Bao'''',FAN Qing-Yu'''',XU Hai-Feng''''.Preparation of adriamycin liposomes conjugated with MDP and its targeting action on Sprague-Dawley rat osteosarcoma tumor model in vivo[J].Journal of the Fourth Military Medical University,1999,20(12):S120-S122. | |
| Authors: | WEN Yil MA Bao-Anl WU Dao-Cheng' HAOXin-Bao' FAN Qing-Yu' XU Hai-Feng' |
| Abstract: | AIM: To make preparation of adriamycin 1ipo-somes conjugated with MDP and to study its anti-tumor ef-fects on Sprague-Dawley rat osteosarooma tumor model invivo. METHoDS= Liposome was prepared by improved re-verse-phase evaporation and conjugation of MDP and encap-sulation of adriamycin was done by transmembrane PH gradi-ent methods. Anti-tumor effects on Spragu-Dawley rats ofosteosarcoma tumor model in vivo were evaluated. RE-SULTS= The average encapsulation rate of adriamycin was92. 3% and conjugation rate of MDP 7O%, with the size of(15O I 35 ) nm in mean diameter by extrusion. Comparedwith that of adriamycin (ADM), the anti-tumor action of 1i-posomal adriamycin conjugated with MDP (MDP~LADM )was significantly enhanced (P |
| Keywords: | doxorabicin liposome osteosarcoma targeting action |
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