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Antiepileptic drug treatment in the nineties in The Netherlands.
Authors:DGA KasteleijnNolst TrenitÄ and PM Edelbroek
Institution:(1) Instituut voor Epilepsiebestrijding, Postbox 21, 2100 AA Heemstede, The Netherlands
Abstract:In this review the lsquostate of the artrsquo of treating patients with epilepsy in the nineties in the Netherlands is presented. It describes general strategies for treatment with antiepileptic drugs and the history of development of the classical anticonvulsant drugs. Eight new drugs, including vigabatrin, lamotrigine, felbamate, oxcarbazepine, gabapentin, tiagabine, levetiracetam and topiramate are discussed. A review of their pharmacological and clinical properties is presented. Dutch experience with these drugs is included.
Keywords:Epilepsy treatment  Antiepileptic drugs  Pharmacology  Pharmacokinetics  Vigabatrin  Lamotrigine  Felbamate  Oxcarbazepine  Gabapentin  Tiagabine  Levetiracetam  Topiramate
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