支撑引流管在胆肠吻合中置放反应的实验研究

目的 研究支撑引流管在胆肠吻合中的置放反应及其病理改变.方法 将8头实验猪随机分为两组,分别实施置管与不置管的胆肠和胆管吻合各2头.喂养3个月后宰杀取标本做病理对照检验.结果 置管组大体解剖显示吻合口炎性增生、管壁硬化增生、管腔挛缩狭窄、有结石形成;病理切片镜下显示胆管黏膜间质中淋巴细胞、浆细胞等慢性炎性细胞浸润,黏膜下大量纤维组织增生.未置管组大体解剖和病理切片仅见轻微炎性改变,且无管腔狭窄.结论 放在体内的异物支撑引流管,不仅不能防止狭窄形成,反而可刺激促进炎性增生、组织硬化和管腔狭窄形成.

An experimental study on place reaction of support drainage tube in cholecystojejunostomy

Objective To investigate the place reaction of support drainage tube in cholecystojejunostomy and its pathological changes.Methods Eight pigs were randomized into 2 groups.The tube-placing cholecystojeunostomy(n=2)or choledochocholedochostomy(n=2)and non-tube-placing cholecystojejunostomy(n=2)or choledochocholedochostomy(n=2)were performed respectively.All the 8 pigs were sarcrificed 3 months after the operation for pathological examination.Results Gross anatomy catheter group showed anastomotic inflammatory hyperplasia, wall hardening hyperplasia,luminal narrow contracture and stone formation.Microscopic biopsy showed bile duct mucosa in interstitial lymphocytes, plasma cells and other chronic inflammatory cell infiltration, a large number of fibrous tissue hyperplasia.However, these features were not found in pigs without placing the tube.Conclusion The tube can not prevent the stenosis.It might promote the formation of stricture since it can stimulate inflammatory hyperplasia and tissue hardening.