| 热休克蛋白70-1基因＋190G/C多态性与牡丹江地区缺血性脑卒中的关系 |
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| 引用本文： | 李晓霞,关红军,张春军,杨勇,郭毓鹏.热休克蛋白70-1基因＋190G/C多态性与牡丹江地区缺血性脑卒中的关系[J].牡丹江医学院学报,2010,31(5):1-3. |
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| 作者姓名： | 李晓霞 关红军 张春军 杨勇 郭毓鹏 |
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| 作者单位： | 牡丹江医学院公共卫生学院,牡丹江,黑龙江,157011 |
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| 基金项目： | 黑龙江省自然科学基金项目，黑龙江省卫生厅重点资助项目 |
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| 摘 要： | 目的：探讨热休克蛋白70-1（HSP70-1）基因多态性与缺血性脑卒中的关系。方法：采用成组病例-对照研究设计,选择牡丹江市各大医院200例缺血性脑卒中患者为病例组,同时选择研究期间社区健康体检人群200人作为对照组。采用聚合酶链反应-限制性片断长度多态性（PCR-RFLP）方法检测HSP70-1多态性,同时按照流行病学方法设计调查表进行问卷调查。结果：HSP70-1基因基因型分布在两组中差异有统计学意义（P=0.013）,＋190G/C（rs562047）多态性增加了缺血性脑卒中的易感性（OR=1.704、P=0.010）。结论：HSP70-1＋190G/C多态性与牡丹江地区汉族总体人群缺血性脑卒中的易感性相关。
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| 关 键 词： | 热休克蛋白70 基因多态性 缺血性脑卒中 |
THE RELATIONSHIP BETWEEN GENETIC POLYMORPHISM OF HEAT SHOCK PROTEIN 70-1 AND SUSCEPTIBILITY TO ISCHEMIC STRODE IN MUDANJIANG |
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| Li Xiao-xia et al.THE RELATIONSHIP BETWEEN GENETIC POLYMORPHISM OF HEAT SHOCK PROTEIN 70-1 AND SUSCEPTIBILITY TO ISCHEMIC STRODE IN MUDANJIANG[J].Journal of Mudanjiang Medical College,2010,31(5):1-3. |
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| Authors: | Li Xiao-xia |
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| Institution: | Li Xiao-xia et al(College of Public Health,Mudanjiang Medical University,Heilongjiang Mudanjiang 157011) |
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| Abstract: | Objective:To explore the association of polymorphisms of heart shock proteins 70-1(HSP 70-1) and the susceptibility to ischemic stroke.Methods: A case-control study was conducted.200 patients with ischemic stroke were selected from several general hospitals in Mudanjiang,200 peaple selected from health population as the control group.HSP70-1 genotypes were determined by the polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) technique.The cases and the control group were interviewed... |
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| Keywords: | heart shock proteins 70-1 polymorphism ischemic stroke |
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