甲型流感病毒宿主特异性研究进展

大量证据显示，哺乳动物甲型流感病毒可能来源于野生水禽。甲型流感病毒由水禽传播给家禽和哺乳动物是近年流感爆发的根源；但不同物种来源的甲型流感病毒不能在其他物种中有效繁殖，表明甲型流感病毒存在宿主特异性。本文简要概述了近年来流感病毒宿主特异性的相关知识及研究进展，重点介绍宿主受体唾液酸衍生物种类、唾液酸一半乳糖基连接键型对病毒感染宿主特异性的影响以及流感病毒血凝素的受体特异性。

Advance in the study of influenza A virus hostspecificity

Ample evidence suggests that influenza viruses in mammals were probably derived from those in wild waterfowl. Influenza A virus have transmitted to both poultry and mammals from waterfowl and caused outbreaks in recent years. But the influenza A virus from one species of animals can not grow efficiently in other species, which indicates the hostspecificity of influenza A virus. This paper reviews current study on the hostspecificity restriction of influenza viruses, focusing on the influence of categories of sialic acid and sialyl linkages on the hosts pecificity, as well as the receptor specificities of the hamagglutinin (HA).