The effect of haloperidol on epinephrine-stimulated adenylate cyclase in humans |
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Authors: | Robert H. Belmaker Richard P. Ebstein Helen Schoenfeld Ranan Rimon |
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Affiliation: | (1) The Jerusalem Mental Health Center-Ezrath Nashim, P.O.B. 140, Jerusalem, Israel |
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Abstract: | Administration of epinephrine in man has been shown previously to lead to a rise in plasma cyclic AMP levels by activation of the -adrenergic-stimulated adenylate cyclase. Therapeutic doses of lithium in humans block the epinephrine-induced rise in plasma cyclic AMP levels, suggesting that lithium inhibits -adrenergic adenylate cyclase. In contrast, ten subjects receiving haloperidol, a drug also effective in the treatment of mania, show a mean rise in plasma cyclic AMP levels after epinephrine administration and the magnitude of the response is the same as for non-drug treated individuals. These findings are discussed in relation to the possible pharmacological mechanisms of action of lithium and haloperidol in the control of mania. |
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Keywords: | Lithium Haloperidol Epinephrine Adenylate cyclase Mania |
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