放射吸收法测量北京地区2884例健康人骨密度研究

目的 利用放射吸收(Radiographic absoptiometry，RA)方法测定骨密度(BMD)，建立北京地区RA测量骨密度参考值数据库。方法 选取北京地区10-92岁健康人2884例，男性1481例，女性1403例，研究对象均详细填写健康调查表格，排除因继发性骨病或服用影响骨代谢药物的病例。用美国CompuMed公司OsteoGram-2000骨密度仪测定所有对象非优势手的第2、3、4指中节指骨(MP2、MP3、MP4)的BMD值，按10岁一个年龄组进行统计分析。结果 峰值骨量(PBM)男性出现在20～29岁，女性20～39岁。男性BMD从30岁开始下降，随年龄增长各年龄段逐渐下降，女性从40岁开始下降。北京女性平均绝经年龄50岁，绝经后骨量快速丢失，绝经后第6～10年丢失最多，达21．38％，绝经后20年平均年骨量丢失率为1．35％。RA测量BMD数据与刘忠厚教授80年代末使用SPA测量40000中国人群中远1／3前臂骨(桡骨、尺骨)结果有极好的相关性。结论 RA测量北京地区健康人峰值骨量和骨量丢失规律与我国部分地区用DXA或SPA方法所得结果相似。

Measurement of bone mineral density by radiographic absorotiometry in 2884 healthy people in Beijing

Objective To study bone mineral density(BMD)by radiographic absorptiometry(RA) , estab-lish the data base of BMD values. Methods The study population consisted of 2884 healthy people aged 10-92 years (1481 males, 1403 females). BMD of middle phalanges of the index, middle and ring fingers (MP2, MP3, MP4)in the non-dominant hand were measured by RA (Compumed, Inc, U. S. A. , OsteoGram-2000) .They were divided into 10-year groups of each for analysis. Results The peak bone mass (PBM) layin 20-29 year group for males and of age whereas thatin 20 - 39 year group for females. The BMD in males decreased with increasing age after 30 years females decreased with increasing age after 40 years of age. The average at age menopause in Beijing women was 50 years. The amual bone loss rate was 1.35% during 20 years after menopause. The results correlated favorably with BMD data of 40000 Chinese investigated in the late 80's using forearm (radius and ulna) single-photon absorptiometry(Liu,et al). Conclusion The regularities of PBM and bone loss measured by RA in Beijing are the same as those by of DXA or SPA in other parts of China.