深圳地区淋球菌株耐药性流行趋势分析

目的了解深圳地区淋球菌临床分离株对抗生素的敏感性以及头孢曲松中敏株的流行特点。方法收集2008年自本地区患者中分离的淋球菌196株,同时整理相应患者信息资料,采用琼脂稀释法测定四环素、环丙沙星、头孢曲松、大观霉素对淋球菌的最低抑菌浓度(MIC),用头孢硝噻吩纸片测定β-内酰胺酶。结果 196株淋球菌中检出产β-内酰胺酶的淋球菌(PPNG)70株(35.71%),质粒介导的高度耐四环素菌株(TRNG)131株(66.84%),对环丙沙星耐药率达95.41%,对头孢曲松中敏率为33.16%,未发现对头孢曲松和大观霉素耐药菌株,对淋球菌头孢曲松中敏株和高敏株进行人群资料分析发现两组的PPNG检出率差异具有统计学意义。结论深圳地区淋球菌耐药性已较严重,头孢曲松中敏株的流行特点尚未明确,应加强对淋球菌耐药性的监测及流行病学的研究。

Trend of drug resistance of Neisseria gonorrhoeae in Shenzhen area in 2008

Aim To understand the trend of resistance of clinical isolated N. gonorrhoeae to antibiotics in Shenzhen area. Methods There 196 N.gonorrhoeoe strains were isolated in 2008 and drug sensitivity tests were carried out. The agar-dilufion method was used to determine the minimum inhibitory concentrations of tetracycline,eiprofloxacin, ceftriaxone and spectinomycin. Penicillinase-producing N. gonorrhoeae was determined ：by using eef＇mase paper. Results Of the total 196 strains , 70 strains produced β-lactamase, while 131 strains showed high plasmid-mediated resistance to tetracycline.The resistant rates to ciprofloxacin was 95.41% and the low sensitive rates to ceftriaxone was 33.16%.All these isolates were susceptible to eefiriaxone and spectinomycin. Conclusion The resistance of N. gonorrhoeae to antibiotics was very serious in Shenzhen area .Research and monitoring of drug resistance of N. gonorrhoeae be carried out.