结肠癌根治术后复发转移危险因素分析

目的]探讨结肠癌患者根治术后复发转移的相关临床病理因素.方法]选择1994年1月至2004年1月行结肠癌根治术患者446例,Cox模型分析临床病理因素与复发转移的关系.结果]全组复发转移率为19.28%.单因素分析显示,发病至手术的时间、术前CEA水平、分化程度、Dukes＇分期、淋巴结转移与术后复发转移有关;多因素分析显示淋巴结转移、分化程度、术前血清CEA水平是术后复发转移预后因素.结论]分化程度、淋巴结转移、术前血清CEA水平是影响结肠癌患者根治术后复发转移的重要预后因素.

Risk Factors for Postoperative Recurrence and Metastasis following Radical Resection of Colon Cancer

Purpose To investigate the clinicopathologic factors related to recurrence and metastasis of colon cancer after radical resection.Methods The clinicopathologic and follow-up data of 446 cases with colon cancer,treated with radical resection from Jan.1994 to Jan.2004 were analyzed by Cox analysis retrospectively.Results The overall recurrence and metastasis rate was 19.28%.Univariate analysis showed that duration from onset to surgery,preoperative serum CEA,histological differentiation,Dukes'stage and lymph node involvement were correlated to recurrence and metastasis in colon cancer.Multivariate analysis showed that lymph node involvement,histological differentiation and preoperative serum CEA were risk factors of recurrence and metastasis.Conclusion Lymph node involvement,histological differentiation and preoperative serum CEA are important prognostic factors with recurrence and metastasis in colon cancer after radical resection.