Structural airway abnormalities in infants and young children with cystic fibrosis |
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Authors: | Long Frederick R Williams Roger S Castile Robert G |
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Affiliation: | Children's Radiological Institute, Children's Hospital, Department of Pediatrics, Ohio State University School of Medicine and Public Health, Children's Hospital and Children's Research Institute, Columbus, Ohio 43205-2696, USA. Flong@chi.osu.edu |
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Abstract: | OBJECTIVES: To determine whether the airway structure of infants and young children with cystic fibrosis (CF) differs from that of normal children by using high-resolution computed tomography (HRCT) imaging. Study design Full-inflation, controlled ventilation HRCT images of the lungs were obtained at four anatomic levels in 34 infants with CF (age, 2.4+/-1.4 years) and 20 control infants (age, 1.8+/-1.4 years). Short axis diameters of all clearly identifiable, round airway/vessel pairs were measured to obtain airway wall thickness (AWT), airway lumen diameter (ALD), and vessel diameter (VD). RESULTS: In infants with CF, mean AWT (+/-SD) was 0.58+/-0.13 mm, ALD was 1.31+/-0.56 mm, and VD was 1.62+/-0.58 mm. In control infants, mean AWT was 0.49+/-0.13 mm, ALD was 1.07+/-0.42 mm, and VD was 1.86+/-0.64 mm. Mean AWT and ALD were greater in children with CF than in normal subjects (P<.001). ALD:VD ratios increased with age in patients with CF compared with control subjects (P=.026). CONCLUSIONS: The airways of infants and young children with CF have thicker walls and are more dilated than those of normal infants. |
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Keywords: | ALD, Airway lumen diameter AOD, Airway outer diameter AWT, Airway wall thickness CF, Cystic fibrosis HRCT, High-resolution computed tomography VD, Vessel diameter |
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