HBV血清学标记携带者转归及其影响因素

本研究通过对HBV血清学标记携带者进行3年随访发现,3年后HBsAg和抗-HBc二标记阴转率为40.27%,3年后HBsAg、抗-HBc、HBeAg和抗-HBe四标记阴转率为30.62%。抗-HBs阳性有助于阴转,阴转率比为1.32,其效应受抗-HBc携带状况所修饰。HBsAg阳性者四标记阴转率有降低趋势。抗-HBc阳性者阴转率低,并且随着携带抗-HBc滴度越高,阴转率越低。文化水平和年龄与阴转呈负相关。进一步研究不同年龄携带者阴转率的差异有助于阐明HBV血清学标记携带者阴转规律及机理。

Conversion of HBV Serological Marker Carriers and Its Influential Factors

485 HBV serological marker carriers were followed up for three years. The three years'' negative conversion rate of both HBsAg and Anti-HBc in carriers was 40.27%. Four markers negative conversion rate of HBsAg, Anti-HBc, HBeAg and Anti-HBe was 30.62% after three years observation. Positive in Anti-HBs is helpful for negative conversion, ratio of negative conversion rates between Anti-HBc positive and negative is 1.32. But the effect of Anti-HBs was modified by Anti-HBc carriage. Negative conversion rate of Anti-HBc carriers was lower, and the higher the Anti-HBc titre, the lower the rate of negative conversion. Educational level and age were negatively correlated with conversion.